Benzene → HCID 22800352、化合物

HRID 1439805ノート

反応式

HRID 1439805 の反応式
[OH:1][C@@H:2]1[CH2:6][C:5](=[O:7])[C:4]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])=[CH:3]1.[CH:17]1[CH:22]=[CH:21][CH:20]=[CH:19]C=1.C1(C)C=CC(S(O)(=O)=[O:30])=CC=1.[O:34]1[CH:39]=[CH:38][CH2:37][CH2:36][CH2:35]1>C(OCC)(=O)C>[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38][CH:39]1[O:1][C@@H:2]1[CH2:6][C:5](=[O:7])[C:4]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([O:16][CH:19]2[CH2:20][CH2:21][CH2:22][CH2:17][O:30]2)=[O:15])=[CH:3]1

参加物

6

反応物 4

HCID 241BenzeneHCID 6101p-Toluenesulfonic acidHCID 80803,4-dihydro-2H-pyranHCID 162131497-[(3R)-3-Hydroxy-5-oxocyclopent-1-en-1-yl]heptanoic acid

生成物 1

HCID 22800352HCID 22800352、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 1.70 parts of 7-(3(R)-hydroxy-5-oxocyclopent-1-en-1-yl)heptanoic acid in 12 parts by volume of dry benzene is added 0.005 part of p-toluenesulfonic acid and 3.40 parts of dihydropyran. The reaction mixture is allowed to stand at room temperature for about 24 hours. The resulting solution is diluted with ethyl acetate, washed with water, dried over anhydrous sodium sulfate, and stripped of solvent under reduced pressure to afford tetrahydropyran-2-yl 7-(3(R)-tetrahydropyran-2-yloxy-5-oxocyclopent-1-en-1-yl)-heptanoate. This compound is represented by the following structural formula. ##STR21##

後処理

  1. washwashed with water
  2. dry with materialdried over anhydrous sodium sulfate

出典と根拠

ORDレコード
ord-f22df2552fc84a519155c4d63e6b4c1d
出典データセット
uspto-grants-1977_11
特許番号
US04060691

反応ノート

読み込み中…