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L-Leucine ethyl ester → (+/-)-N-[2-(acetylthiomethyl)-4-methyl-1-oxopentyl]-L-leucine, ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Leucine ethyl ester | HCID 75971 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-[(Acetylthio)methyl]-4-methylpentanoyl chloride | HCID 12769074 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (+/-)-N-[2-(acetylthiomethyl)-4-methyl-1-oxopentyl]-L-leucine, ethyl ester | HCID 131719291 | — |
反応手順
2-Acetylthiomethyl-4-methylpentanoyl chloride and (L)-leucine, ethyl ester are reacted in methylene chloride in the presence of diisopropylethylamine at a temperature below 0° according to the procedure of Example 26 to yield (±)-N-[2-(acetylthiomethyl)-4-methyl-1-oxopentyl]-L-leucine, ethyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05496805 |
| 出典データセット | uspto-grants-1996_03 |
| ORD ID | ord-5431d0014d5a41f09bda713037b05564 |
| 出典メモ | uspto-grants-1996_03 |