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HRID1440074

反应详情

EQUATION

反应方程式

HRID 1440074 的结构方程式

REACTANTS

反应物

3
结构：CCOC(=O)[C@@H](N)CC(C)C
HCID75971

O-Ethyl-L-leucine

C8H17NO2

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：CC(=O)SCC(CC(C)C)C(=O)Cl
HCID12769074

S-[2-(Chlorocarbonyl)-4-methylpentyl] ethanethioate

C9H15ClO2S

PRODUCTS

生成物

1
结构：CCOC(=O)[C@H](CC(C)C)NC(=O)C(CSC(C)=O)CC(C)C
HCID131719291

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

2-Acetylthiomethyl-4-methylpentanoyl chloride and (L)-leucine, ethyl ester are reacted in methylene chloride in the presence of diisopropylethylamine at a temperature below 0° according to the procedure of Example 26 to yield (±)-N-[2-(acetylthiomethyl)-4-methyl-1-oxopentyl]-L-leucine, ethyl ester.