関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrazine | HCID 9321 | — |
| 反応物 | 4-(2,4-Difluorophenyl)-1,1,1-trifluoro-4-hydroxy-3-buten-2-one | HCID 69934778 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | HCID 178505511 | HCID 178505511 | 94% |
反応手順
At 24° C., 15.0 g (0.06 mole) of the product of step A was dissolved in 50 mL glacial acetic acid and treated with 2 mL (0.064 mole) anhydrous hydrazine, added over a period of 5 minutes. The reaction was heated to 95° C. for 30 minutes. The reaction was cooled and poured into 300 mL ice water. The slurry was filtered and the cake washed with water and air dried to give 13.86 g (94%) of 5-(2,4-difluorophenyl)-3-(trifluoromethyl)-1H-pyrazole as a white solid, mp 157°-158° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05496956 |
|---|
| 出典データセット | uspto-grants-1996_03 |
|---|
| ORD ID | ord-22ddc8d1a5384d2b9ad58352f3fa5d2f |
|---|
| 出典メモ | uspto-grants-1996_03 |
|---|
