Sodium Hydroxide → 2-{1-[(7-Chloro-1,8-naphthyridin-2-yl)amino]-6-methyl-3-oxoheptyl}benzoic acid

HRID 1440306ノート

反応式

HRID 1440306 の反応式
[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([N:12]3[C:20](=[O:21])[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH:13]3[CH:22]([C:26](=[O:32])[CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])C(O)=O)=[N:9]2)=[CH:4][CH:3]=1.[OH-:33].[Na+]>O>[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([NH:12][CH:13]([C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=3[C:20]([OH:21])=[O:33])[CH2:22][C:26](=[O:32])[CH2:27][CH2:28][CH:29]([CH3:30])[CH3:31])=[N:9]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 18983252(+/-)-2-[2-(7-Chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl]-6-methyl-3-oxoheptanoic acid

生成物 1

HCID 98025152-{1-[(7-Chloro-1,8-naphthyridin-2-yl)amino]-6-methyl-3-oxoheptyl}benzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
20 °C

実験手順

A suspension of 30 mg of (±)-2-[2-(7-chloro-1,8-naphthyridin-2-yl)-3-oxo-1-isoindolinyl]-6-methyl-3-oxoheptanoic acid in 4.7 cm3 of distilled water and 1.32 cm3 of a 0.1N aqueous sodium hydroxide solution is stirred at a temperature of approximately 20° C. for 72 hours. An insoluble product is removed by filtration and the filtrate is acidified to a pH=2 by addition of a 0.1N aqueous hydrochloric acid solution. The precipitate obtained is separated by filtration, washed with water and dried in air. 10 mg of (±)-2-{1-[(7-chloro-1,8-naphthyridin-2-yl)amino]-6-methyl-3-oxoheptyl}benzoic acid are thus obtained whose characteristics are identical to those of the product of Example 1.

後処理

  1. customAn insoluble product is removed by filtration
  2. additionthe filtrate is acidified to a pH=2 by addition of a 0.1N aqueous hydrochloric acid solution
  3. customThe precipitate obtained
  4. customis separated by filtration
  5. washwashed with water
  6. customdried in air

出典と根拠

ORDレコード
ord-c056f0b9b2854032983d2e7383d78e55
出典データセット
uspto-grants-1996_03
特許番号
US05498716

反応ノート

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