Trifluoroacetic acid → 5,6-Dihydroxyindole

HRID 1440373ノート

反応式

HRID 1440373 の反応式
C([O:8][C:9]1[C:19]([O:20]CC2C=CC=CC=2)=[CH:18][C:12]([CH:13]=[CH:14][N+:15]([O-:17])=[O:16])=[C:11]([N+:28]([O-:30])=[O:29])[CH:10]=1)C1C=CC=CC=1.FC(F)(F)C(O)=O>>[OH:20][C:19]1[CH:18]=[C:12]2[C:11](=[CH:10][C:9]=1[OH:8])[NH:28][CH:14]=[CH:13]2.[OH:8][C:9]1[C:19]([OH:20])=[CH:18][C:12]([CH:13]=[CH:14][N+:15]([O-:17])=[O:16])=[C:11]([N+:28]([O-:30])=[O:29])[CH:10]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 542653754,5-Dibenzyloxy-2,beta-dinitrostyrene

生成物 2

HCID 1146835,6-DihydroxyindoleHCID 537371624-Nitro-5-(2-nitroethenyl)benzene-1,2-diol

実験手順

or by debenzylation of 4,5-dibenzyloxy-2,β-di-nitrostyrene; in this case the debenzylation is performed by means of trifluoroacetic acid. In a second stage 5,6-dihydroxyindole is obtained from 4,5-dihydroxy-2,β-di-nitrostyrene as indicated above (U.S. Pat. No. 4,595,765).

出典と根拠

ORDレコード
ord-8b59e298c5734d82a89c2b0a69d0d239
出典データセット
uspto-grants-1996_03
特許番号
US05498746

反応ノート

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