Triethylamine → Methyl 2-pentanoylaminothiophene-3-carboxylate

HRID 1440796

反応式

HRID 1440796 の反応式
[C:1](Cl)(=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5].[NH2:8][C:9]1[S:10][CH:11]=[CH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15].C(N(CC)CC)C>ClC(Cl)C>[C:1]([NH:8][C:9]1[S:10][CH:11]=[CH:12][C:13]=1[C:14]([O:16][CH3:17])=[O:15])(=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 61186Valeryl chlorideHCID 78381Methyl 2-amino-3-thenoate

生成物 1

HCID 18982094Methyl 2-pentanoylaminothiophene-3-carboxylate収率 96%

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

実験手順

Valeryl chloride (1.3 g) was added to a solution of methyl 2-aminothiophene-3-carboxylate (1.6 g) [Y. Kuwada et al. Chem. Abst. 82, 156252(1975)] and triethylamine (1.2 g) in dichloroethane (20 ml) under ice-cooling. The mixture was stirred for two hours. The reaction mixture was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled under reduced pressure. The residue was purified by column chromatography on silica gel to afford the title compound as a colorless oil (2.3 g, 96%).

後処理

  1. washThe reaction mixture was washed with water
  2. dry with materialdried over anhydrous magnesium sulfate
  3. distillationThe solvent was distilled under reduced pressure
  4. customThe residue was purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-a8d80564f5a44863b04abaf178b07cb0
出典データセット
uspto-grants-1996_03
特許番号
US05500427

関連ノート

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