Tributylstannane → 4,4-Dimethylhexanenitrile
反応式
C([SnH](CCCC)CCCC)CCC.Br[C:15]([CH3:19])([CH2:17][CH3:18])[CH3:16].[C:20](#[N:23])[CH:21]=[CH2:22]>C1C=CC=CC=1>[CH3:16][C:15]([CH3:19])([CH2:17][CH3:18])[CH2:22][CH2:21][C:20]#[N:23]参加物
5
実験手順
Tri n-butyl tin hydride (19.6 ml.) and α-azo-iso-butyronitrile (0.5 g.) were added succesively to a stirred solution of 2-bromo-2-methylbutane (10 g.) and acrylonitrile (43.5 ml.) in dry benzene (200 ml.). The mixture was heated at reflux for 6 hours, cooled and filtered. The residue was washed with diethyl ether (50 ml.) and the combined filtrates evaporated under reduced pressure. 4,4-Dimethylhexanenitrile was obtained as a colourless liquid (2.1 g.), b.p. 85°-94°/20 mm.
後処理
- temperatureThe mixture was heated
- temperatureat reflux for 6 hours
- temperaturecooled
- filtrationfiltered
- washThe residue was washed with diethyl ether (50 ml.)
- customthe combined filtrates evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-24595ab858774dd5aea8dfad00a866a8
- 出典データセット
- uspto-grants-1996_03
- 特許番号
- US05502073
反応ノート
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