4-Toluenesulfonyl chloride → N-[5-bromo-3-hydroxypyridin-2-yl]-4-methylbenzenesulfonamide

反応式

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Br:12][C:13]1[CH:14]=[C:15]2[O:21]C(=O)[NH:19][C:16]2=[N:17][CH:18]=1.[OH-].[Na+]>>[Br:12][C:13]1[CH:14]=[C:15]([OH:21])[C:16]([NH:19][S:8]([C:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][CH:4]=2)(=[O:10])=[O:9])=[N:17][CH:18]=1

参加物

反応物 3

HCID 73974-Toluenesulfonyl chloride

HCID 14798Sodium Hydroxide

HCID 136144586-Bromo-3H-oxazolo(4,5-b)pyridin-2-one

生成物 1

HCID 23122883N-[5-bromo-3-hydroxypyridin-2-yl]-4-methylbenzenesulfonamide

実験手順

With 4-methylbenzenesulfonyl chloride, 6-bromo-[1,3]-oxazolo[4,5-b]pyridin-2(3H)-one (described in Heterocycles, 41, 2799 (1995)) was allowed to react. Then, with an aqueous solution of sodium hydroxide, the mixture was hydrolyzed to give the title compound having the following physical data.