2-Nitro-4-vinyl-benzoic acid methyl ester → Methyl 2-amino-4-ethylbenzoate
反応式
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[CH2:11])=[CH:6][C:5]=1[N+:12]([O-])=O>CO.[Pd]>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH3:11])=[CH:6][C:5]=1[NH2:12]参加物
4
実験手順
A solution of 2-nitro-4-vinyl-benzoic acid methyl ester (820 mg, 3.96 mmol) in MeOH (15 mL) was shaken under H2 (0.1 bar) in the presence of Pd/C (10%, 0.2 g) at 50° C. for 5 h. After cooling to r.t., the reaction mixture was filtered and the solvent was removed in vacuo to provide the title product (680 mg, 96%) which was used in the next step without further purification. ESI-MS: m/z 180.1 [M+H]+, rt 5.13 min
後処理
- filtrationthe reaction mixture was filtered
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-faba1b00be784d95b9cb83317cf0eac2
- 出典データセット
- uspto-grants-2010_02
- 特許番号
- US07655666B2
反応ノート
読み込み中…