Trifluoroacetic acid → 4-(2-Aminoethyl)benzonitrile

HRID 1441686ノート

反応式

HRID 1441686 の反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=1)(C)(C)C.FC(F)(F)C(O)=O.C(OCC)(=O)C>ClCCl>[NH2:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=1

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 8857Ethyl AcetateHCID 21955533tert-Butyl 4-cyanophenethylcarbamate

生成物 1

HCID 219125254-(2-Aminoethyl)benzonitrile

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.90 g commercially available [2-(4-Cyano-phenyl)-ethyl]-carbamic acid tert-butyl ester were dissolved in 100 ml dichloromethane. 10 ml trifluoroacetic acid were added and the reaction mixture was stirred at room temperature for one hour. 250 ml ethyl acetate were added and the mixture was washed three times with saturated NaHCO3 solution. The organic layer was dried over MgSO4 and then the solvent was removed in vacuo to obtain 700 mg 4-(2-Amino-ethyl)-benzonitrile as pale yellow solid.

後処理

  1. washthe mixture was washed three times with saturated NaHCO3 solution
  2. dry with materialThe organic layer was dried over MgSO4
  3. customthe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-1f50f452ad114a5f9558744c8ad85374
出典データセット
uspto-grants-2010_02
特許番号
US07655679B2

反応ノート

読み込み中…