Butanal → 4-(2-Butylamino-ethyl)-benzonitrile

HRID 1441687ノート

反応式

HRID 1441687 の反応式
[NH2:1][CH2:2][CH2:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=1.[CH:12](=O)[CH2:13][CH2:14][CH3:15].[BH4-].[Na+].C(OCC)(=O)C>CO>[CH2:12]([NH:1][CH2:2][CH2:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[CH:6][CH:5]=1)[CH2:13][CH2:14][CH3:15]

参加物

6

反応物 4

HCID 261ButanalHCID 8857Ethyl AcetateHCID 4311764Sodium borohydrideHCID 219125254-(2-Aminoethyl)benzonitrile

生成物 1

HCID 591645764-(2-Butylamino-ethyl)-benzonitrile

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

700 mg 4-(2-Amino-ethyl)-benzonitrile and 63 μl Butyraldehyde were dissolved in 20 ml methanol. 1.0 g molecular sieves 4 Angström were added the mixture was stirred at room temperature for two hours. Then 270 mg sodium borohydride were added and the mixture was stirred for an additional hour at room temperature. 100 ml ethyl acetate were added, and the reaction was quenched by addition of 1 ml water. The reaction mixture was filtered through a pad of celite and MgSO4. The filtrate was evaporated in vacuo to provide 750 mg crude 4-(2-Butylamino-ethyl)-benzonitrile. This material was used without further purification.

後処理

  1. addition1.0 g molecular sieves 4 Angström were added the mixture
  2. stirringthe mixture was stirred for an additional hour at room temperature
  3. customthe reaction was quenched by addition of 1 ml water
  4. filtrationThe reaction mixture was filtered through a pad of celite and MgSO4
  5. customThe filtrate was evaporated in vacuo

出典と根拠

ORDレコード
ord-96df91b9c81e4bd188f03779ff4c065c
出典データセット
uspto-grants-2010_02
特許番号
US07655679B2

反応ノート

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