1-methyl-5-nitro-2(1H)-pyridinone → 5-Amino-1-methyl-1,2-dihydropyridin-2-one

HRID 1441731ノート

反応式

HRID 1441731 の反応式
[CH3:1][N:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]1=[O:11]>CO.CC(O)=O.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3](=[O:11])[N:2]([CH3:1])[CH:7]=1

参加物

5

反応物 1

HCID 2958661-methyl-5-nitro-2(1H)-pyridinone

生成物 1

HCID 102200055-Amino-1-methyl-1,2-dihydropyridin-2-one

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒HCID 887Methanol溶媒

実験手順

A solution of compound 50B (200 mg, 1.298 mmol) and 10% Pd/C (˜5 mg) in MeOH and AcOH was stirred under H2 at 1 atmosphere for 30 minutes. The reaction solution was filtered through a pad of celite eluting with MeOH. The MeOH was removed under reduced pressure to give compound 50C.

後処理

  1. filtrationThe reaction solution was filtered through a pad of celite
  2. washeluting with MeOH
  3. customThe MeOH was removed under reduced pressure

出典と根拠

ORDレコード
ord-6bff92f6f0fa413cbb9b190ca49314cb
出典データセット
uspto-grants-2010_02
特許番号
US07655688B2

反応ノート

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