Sodium Hydroxide → 5-Chloronaphthalen-1-amine

HRID 1441789ノート

反応式

HRID 1441789 の反応式
[NH:1]([C:5]1[C:14]2[C:9](=[C:10]([Cl:15])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=1)C(C)=O.[OH-].[Na+]>CCO>[NH2:1][C:5]1[C:14]2[C:9](=[C:10]([Cl:15])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 218748441-Acetamino-5-chloronaphthalene

生成物 1

HCID 44550535-Chloronaphthalen-1-amine収率 98%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of the above synthesized 1-acetamino-5-chloronaphthalene (52 mg, 0.24 mmol) in 3 mL EtOH was heated to reflux and treated with 0.5 mL 40% aqueous NaOH solution. The mixture was refluxed until no more starting material could be detected, cooled and concentrated under reduced pressure. The residue was taken up in CH2Cl2 (50 mL) and was washed with H2O (25 mL). The organic layer was dried over MgSO4 and concentrated in vacuo to leave 41 mg (98%) of compound 213A as a white solid.

後処理

  1. temperaturewas heated
  2. temperatureto reflux
  3. temperatureThe mixture was refluxed until
  4. temperaturecooled
  5. concentrationconcentrated under reduced pressure
  6. washwas washed with H2O (25 mL)
  7. dry with materialThe organic layer was dried over MgSO4
  8. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-36676154c98e4d0089e339b673e1e3b5
出典データセット
uspto-grants-2010_02
特許番号
US07655689B2

反応ノート

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