2-Chloro-3-iodo-5-nitropyridine → 5-Amino-2-chloro-3-iodopyridine
反応式
[Cl:1][C:2]1[C:7]([I:8])=[CH:6][C:5]([N+:9]([O-])=O)=[CH:4][N:3]=1>[Fe]>[NH2:9][C:5]1[CH:6]=[C:7]([I:8])[C:2]([Cl:1])=[N:3][CH:4]=1参加物
3
実験手順
2-Chloro-3-iodo-5-nitropyridine (0.25 g, 0.88 mmol) was reacted with iron powder (0.25 g, 4.4 mmol) in the manner described in example 762D. Removal of the solvent in vacuo gave compound 765C (0.172 g, 77%). as a golden yellow solid. HPLC: 100% at 2.32 min(YMC S5 ODS column) eluting with 10-90% aqueous methanol containing 0.2% phosphoric acid over a 4 min gradient monitoring at 220 nm. MS (ES): m/z 255.03 [M+H]+.
後処理
- customRemoval of the solvent in vacuo
出典と根拠
- ORDレコード
- ord-d79a5cff7cc044048c6660314a4f8532
- 出典データセット
- uspto-grants-2010_02
- 特許番号
- US07655689B2
反応ノート
読み込み中…