Dextroamphetamine → Lisdexamfetamine Dimesylate

HRID 1442489

反応式

HRID 1442489 の反応式
[S:1]([OH:5])(O)(=[O:3])=[O:2].[NH2:6][CH:7]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:8].[NH2:16][C@H:17]([C:23](O)=[O:24])[CH2:18][CH2:19][CH2:20][CH2:21][NH2:22].[CH3:26][C@H](N)CC1C=CC=CC=1.[CH3:36][C@H](N)CC1C=CC=CC=1>O>[CH3:8][C@H:7]([NH:6][C:23]([C@@H:17]([NH2:16])[CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])=[O:24])[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH3:26][S:1]([OH:5])(=[O:3])=[O:2].[CH3:36][S:1]([OH:5])(=[O:3])=[O:2]

参加物

5

反応物 3

HCID 5826Dextroamphetamine2 回HCID 222898AmphedrineHCID 131727865L-lysine d-amphetamine

生成物 1

HCID 11597697Lisdexamfetamine Dimesylate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Male Sprague-Dawley rats were provided water ad libitum, fasted overnight, and dosed by oral gavage with 1.5, 3, 6, 12, and 60 mg/kg of amphetamine sulfate or L-lysine-d-amphetamine containing the equivalent amounts of d-amphetamine. Concentrations of d-amphetamine were measured by ELISA.

出典と根拠

ORDレコード
ord-be634dd2ffce4a8598c4c234fbe793f6
出典データセット
uspto-grants-2010_02
特許番号
US07659253B2

関連ノート

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