HCID 22185398、化合物 → HCID 22185405、化合物

HRID 1442651ノート

反応式

HRID 1442651 の反応式
[CH3:1][O:2][C:3]1[CH:17]=[C:16]([N+:18]([O-])=O)[CH:15]=[CH:14][C:4]=1[O:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[H][H]>CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3]1[CH:17]=[C:16]([NH2:18])[CH:15]=[CH:14][C:4]=1[O:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1

参加物

5

反応物 2

HCID 22185398HCID 22185398、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 22185405HCID 22185405、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 10% Pd/C (0.25 g) was added to a solution of 4-[2-(2-methoxy-4-nitro-phenoxy)-ethyl]-morpholine Compound 42a3 (1.4 g, 5.0 mmol) in EtOAc (50 mL). The solution was exposed to 40 PSI of hydrogen gas for a period of 1 hr. The catalyst was removed by filtration through Celite 545 and the solvent was removed to give 3-methoxy-4-(2-morpholin-4-yl-ethoxy)-phenylamine Compound 42a (1.1 g). MS 253 (MH+).

後処理

  1. customThe catalyst was removed by filtration through Celite 545
  2. customthe solvent was removed

出典と根拠

ORDレコード
ord-286890e9bbaf4481b916e52e78d4eafd
出典データセット
uspto-grants-2010_02
特許番号
US07659284B2

反応ノート

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