Water → 5-aminoisoquinolin-1(2H)-one

HRID 1443125ノート

反応式

HRID 1443125 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][NH:8][C:9]2=[O:14])([O-])=O.[Cl-].[NH4+].O>C(O)C.O1CCCC1.[Zn]>[NH2:1][C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][NH:8][C:9]2=[O:14]

参加物

7

反応物 3

HCID 962WaterHCID 25517Ammonium ChlorideHCID 2313785-Nitro-1,2-dihydroisoquinolin-1-one

生成物 1

HCID 20725-aminoisoquinolin-1(2H)-one収率 88.1%

試薬・触媒・溶媒 3

HCID 23994Zinc触媒HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

268.3 mg (1.51 mmol) of 5-nitroisoquinolin-1(2H)-one is added with 376.5 mg of ammonium chloride and 2.6 ml of water in 14 ml of ethanol and 5.4 ml of tetrahydrofuran. After addition in portions of 1.23 g of zinc powder (heating to 30 to 35° C.), it is stirred for two hours. The reaction mixture is suctioned off through a glass fiber filter and rewashed with ethyl acetate. After the filtrate is washed with water and saturated sodium chloride solution, the organic phase is dried as usual. Filtering off the desiccant and spinning off the solvent produce 196.5 mg (88.1%) of the desired amine.

後処理

  1. filtrationfilter
  2. washAfter the filtrate is washed with water and saturated sodium chloride solution
  3. customthe organic phase is dried as usual
  4. filtrationFiltering off the desiccant and

出典と根拠

ORDレコード
ord-f3e83587e7474dd99b6b74e9872daf2f
出典データセット
uspto-grants-2010_02
特許番号
US07659297B2

反応ノート

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