Methanol → 5-Methyl-1H-indazol-4-amine

HRID 1443220ノート

反応式

HRID 1443220 の反応式
Cl[C:2]1[C:3]([NH2:11])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.[CH3:12]O>[Pd]>[CH3:12][C:2]1[C:3]([NH2:11])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2

参加物

4

反応物 2

HCID 887MethanolHCID 179892615-Chloro-1H-indazol-4-amine

生成物 1

HCID 193544325-Methyl-1H-indazol-4-amine収率 6%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

Analogously to the production of 5-chloro-1H-indazol-4-ylamine, the regioisomeric mixture of the previous reaction (1.0 g, 5.64 mmol)) is reacted with 100 mg of palladium on carbon in methanol under hydrogen atmosphere for 16 hours at room temperature. After purification on silica gel with hexane/ethyl acetate (33% hexane, then 100% ethyl acetate), 53 mg (6% of theory) of 5-methyl-1H-indazol-4-ylamine is obtained.

後処理

  1. customAfter purification on silica gel with hexane/ethyl acetate (33% hexane

出典と根拠

ORDレコード
ord-bbca41883f3043539429aa866db67940
出典データセット
uspto-grants-2010_02
特許番号
US07659297B2

反応ノート

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