2-Bromo-1-(2,5-dichlorophenyl)ethanone → 1-Benzo[1,3]dioxol-4-yl-2-bromo-ethanone

HRID 1443371

反応式

HRID 1443371 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C:10](=[O:12])[CH3:11])[C:4]=2[O:3][CH2:2]1.[Br:13]CC(C1C=C(Cl)C=CC=1Cl)=O>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C:10](=[O:12])[CH2:11][Br:13])[C:4]=2[O:3][CH2:2]1

参加物

3

反応物 2

HCID 27569072-Bromo-1-(2,5-dichlorophenyl)ethanoneHCID 137310061-(1,3-Dioxaindan-4-yl)ethan-1-one

生成物 1

HCID 218649771-Benzo[1,3]dioxol-4-yl-2-bromo-ethanone収率 48%

実験手順

This compound was prepared from 1-benzo[1,3]dioxol-4-yl-ethanone (2.15 g, 13.1 mmol) in the manner described for 2-bromo-1-(2,5-dichlorophenyl)ethanone (Example I-2), affording 1.54 g (48%) of 1-benzo[1,3]dioxol-4-yl-2-bromo-ethanone as an off-white solid. 1H-NMR (CD2Cl2) δ; 7.41 (dd, J=8.1 Hz, 1H), 7.05 (dd, J=8.1 Hz, 1 H), 6.94 (dd, J=8.8 Hz, 1H), 6.13 (s, 2H), 4.55 (s, 2H). TLC Rf=0.28, 15%, ethyl acetate-hexanes.

出典と根拠

ORDレコード
ord-5143ea45ae794d5a947696bd090bb286
出典データセット
uspto-grants-2010_02
特許番号
US07659412B2

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