Citric Acid → 1-Chloro-4-methoxy-5-methyl-2-nitrobenzene
反応式
[Cl:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][C:5]([OH:11])=[C:4]([CH3:12])[CH:3]=1.[C:13](=O)([O-])[O-].[K+].[K+].CI.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]([O:11][CH3:13])=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]参加物
6
実験手順
To a stirred solution of 4-chloro-2-methyl-5-nitrophenol (18.8 g, 100 mmol) in DMF (200 ml) was added potassium carbonate (13.8 g, 100 mmol) and methyl iodide (21.3 g, 150 mmol). The mixture was stirred for about two hours at room temperature. 5% Citric acid was added and the mixture was extracted three times with ethyl acetate. The organic phase was washed with brine, dried with sodium sulphate and evaporated under reduced pressure which gave the title compound (20 G, 100%).
後処理
- extractionthe mixture was extracted three times with ethyl acetate
- washThe organic phase was washed with brine
- dry with materialdried with sodium sulphate
- customevaporated under reduced pressure which
出典と根拠
- ORDレコード
- ord-b9ad01e20d3643a9bdf09246d02b8172
- 出典データセット
- uspto-grants-2010_02
- 特許番号
- US07659245B2
反応ノート
読み込み中…