Hydrochloric Acid → 1-Methylpiperidine-2-carboxylic acid

HRID 1443639ノート

反応式

HRID 1443639 の反応式
C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH2:9][CH2:8][N:7]1[CH3:12])=[O:5])C.[OH-].[Na+].Cl>CO.O>[CH3:12][N:7]1[CH2:8][CH2:9][CH2:10][CH2:11][CH:6]1[C:4]([OH:5])=[O:3]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 566742Ethyl 1-methylpiperidine-2-carboxylate

生成物 1

HCID 4159391-Methylpiperidine-2-carboxylic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

N-Methyl-piperidine-2-carboxylic acid ethyl ester (5.1 g) was dissolved in a mixture of 100 ml methanol and 10 ml water. NaOH (8 g) was added and the reaction mixture was stirred at room temperature overnight. The solution was then neutralized with hydrochloric acid, evaporated to dryness, and evaporated four times with toluene. The resulting powdery residue was used directly in the next step.

後処理

  1. customevaporated to dryness
  2. customevaporated four times with toluene

出典と根拠

ORDレコード
ord-e8a0cbe07a1f4296b63f9c32d27ef491
出典データセット
uspto-grants-2010_02
特許番号
US07662786B2

反応ノート

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