2-Azido-1-(2-methoxyphenyl)ethanone → 2-Amino-1-(2-methoxyphenyl)ethanone
反応式
[N:1]([CH2:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH3:14])=[O:6])=[N+]=[N-]>CO.Cl.[Pd]>[NH2:1][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH3:14])=[O:6]参加物
5
実験手順
Dissolve 2-azido-1-(2-methoxy-phenyl)-ethanone (3.54 g, 18.5 mmol) in 1328 ml of MeOH and 9 ml of concentrated HCl. Add 943 mg of 10% Pd/C and expose the reaction mixture to 60 psi of H2 for 5 hours at ambient temperature. Filter the catalyst off through a pad of celite and concentrate the filtrate in vacuo to afford 3.74 g of crude 2-amino-1-(2-methoxyphenyl)-ethanone as the hydrochloride salt.
後処理
- customfor 5 hours
- customat ambient temperature
- filtrationFilter the catalyst off through a pad of celite
- concentrationconcentrate the filtrate in vacuo
出典と根拠
- ORDレコード
- ord-2e7cde3ef9e04e819759b43819eeee97
- 出典データセット
- uspto-grants-2010_02
- 特許番号
- US07662771B2
反応ノート
読み込み中…