Lithium Hydroxide → [5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid

HRID 1443998ノート

反応式

HRID 1443998 の反応式
C[O:2][C:3](=[O:26])[CH2:4][S:5][C:6]1[CH:11]=[N:10][C:9]([NH:12][S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:17]=2[Cl:23])(=[O:15])=[O:14])=[C:8]([O:24][CH3:25])[N:7]=1.[OH-].[Li+]>CO.O>[Cl:23][C:17]1[C:18]([Cl:22])=[CH:19][CH:20]=[CH:21][C:16]=1[S:13]([NH:12][C:9]1[N:10]=[CH:11][C:6]([S:5][CH2:4][C:3]([OH:26])=[O:2])=[N:7][C:8]=1[O:24][CH3:25])(=[O:15])=[O:14]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 58597364[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid methyl ester

生成物 1

HCID 59168222[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

[5-(2,3-Dichlorobenzenesulphonylamino)-6-methoxy-2-pyrazinylsulphanyl]acetic acid methyl ester (Example 82) (0.1 g) and lithium hydroxide (0.04 g) in methanol (5 mL) and water (1 mL) was stirred at room temperature. After 2 h, the mixture was evaporated and saturated aqueous citric acid (5 mL) added. The white solid was collected, washed with water and dried. Yield 0.07 g.

後処理

  1. customthe mixture was evaporated
  2. additionsaturated aqueous citric acid (5 mL) added
  3. customThe white solid was collected
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-906e0b1595c0450b828a2ddb0d1a53a6
出典データセット
uspto-grants-2010_02
特許番号
US07662825B2

反応ノート

読み込み中…