Chlorosulfonic acid → 2,3-Dichloro-4-fluorobenzenesulphonyl chloride

HRID 1444061ノート

反応式

HRID 1444061 の反応式
[Cl:1][S:2]([OH:5])(=O)=[O:3].[Cl:6][C:7]1[C:12]([Cl:13])=[C:11]([F:14])[CH:10]=[CH:9][CH:8]=1>ClCCl>[Cl:6][C:7]1[C:12]([Cl:13])=[C:11]([F:14])[CH:10]=[CH:9][C:8]=1[S:2]([Cl:1])(=[O:5])=[O:3]

参加物

4

反応物 2

HCID 24638Chlorosulfonic acidHCID 119011Benzene, 1,2-dichloro-3-fluoro-

生成物 1

HCID 591682102,3-Dichloro-4-fluorobenzenesulphonyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Chlorosulphonic acid (12.1 mL) was added dropwise to a solution of 2,3-dichloro-4-fluorobenzene (5.0 g) in dichloromethane (12 mL) at −40° C. The solution was allowed to slowly warm to room temperature and was stirred for 3 days. The solution was poured onto crushed ice/water, extracted into dichloromethane and concentrated under reduced pressure. Purified by silica gel chromatography eluting with dichloromethane/iso-hexane mixtures. Yield 4.2 g

後処理

  1. additionThe solution was poured
  2. extractionextracted into dichloromethane
  3. concentrationconcentrated under reduced pressure
  4. customPurified by silica gel chromatography
  5. washeluting with dichloromethane/iso-hexane mixtures

出典と根拠

ORDレコード
ord-001cf7c4f41947348184231ea08ab170
出典データセット
uspto-grants-2010_02
特許番号
US07662825B2

反応ノート

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