Hydrochloric Acid → HCID 67020462、化合物

HRID 1444097ノート

反応式

HRID 1444097 の反応式
[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([C:15]([O:17]CC)=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:20]>[OH-].[Na+]>[ClH:20].[C:1]1([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 18997131HCID 18997131、化合物

生成物 1

HCID 67020462HCID 67020462、化合物

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A suspension of 1-(2-phenylethyl)-4-carbetoxypiperidine (12.2 g, 0.047 mol) obtained as described in J. Med. Chem. 1996 (39), 749-756, in 1N NaOH (100 ml) was heated under reflux for 4 h. After cooling to room temperature, the solution was made acid with 6N HCl to pH 2, concentrated by evaporation at reduced pressure, and the solid thus obtained was filtered and dried in a stove under vacuum to give the desired product (12.1 g).

後処理

  1. customobtained
  2. temperatureunder reflux for 4 h
  3. concentrationconcentrated by evaporation at reduced pressure
  4. customthe solid thus obtained
  5. filtrationwas filtered
  6. customdried in a stove under vacuum

出典と根拠

ORDレコード
ord-74077a545b0d4b89a7b912a4c041a658
出典データセット
uspto-grants-2010_02
特許番号
US07662836B2

反応ノート

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