Dimethylformamide → 2-Chloro-7,7-difluoro-5-methyl-9-(2-thiophen-2-yl-ethyl)-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-one

反応式

[C:23](=[O:24])([O-:25])[O-:26].[CH3:31][N:32]([CH3:33])[CH:34]=[O:35].[Cl:1][c:2]1[n:3][cH:4][c:5]2[c:6]([n:22]1)[N:7]([CH2:15][CH2:16][c:17]1[s:18][cH:19][cH:20][cH:21]1)[CH2:8][C:9]([F:13])([F:14])[C:10](=[O:12])[NH:11]2.[Cs+:27].[Cs+:28].[I:29][CH3:30]>>[Cl:1][c:2]1[n:3][cH:4][c:5]2[c:6]([n:22]1)[N:7]([CH2:15][CH2:16][c:17]1[s:18][cH:19][cH:20][cH:21]1)[CH2:8][C:9]([F:13])([F:14])[C:10](=[O:12])[N:11]2[CH3:23]