Potassium Carbonate → 4-Piperidinopiperidine-1-carbonyl chloride

HRID 1444683

反応式

HRID 1444683 の反応式
Cl.[N:2]1([CH:8]2[CH2:13][CH2:12][N:11]([C:14]([Cl:16])=[O:15])[CH2:10][CH2:9]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.C([O-])([O-])=O.[K+].[K+]>C(Cl)Cl>[N:2]1([CH:8]2[CH2:9][CH2:10][N:11]([C:14]([Cl:16])=[O:15])[CH2:12][CH2:13]2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 116375531-Chlorocarbonyl-4-piperidinopiperidine hydrochloride

生成物 1

HCID 98133754-Piperidinopiperidine-1-carbonyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

[1,4′]bipiperidinyl-1′-carbonyl chloride hydrochloride (9.7 g), methylene chloride (150 ml) and K2CO3 (10.5 g, 2.1 ekv) were charged. The mixture was stirred for about 1 hour. The solution was filtered and the cake washed with 10 ml of methylene chloride. The solution (containing 8.4 g of [1,4′]bipiperidinyl-1′-carbonyl chloride) can be used as such for the preparation of Irinotecan

後処理

  1. filtrationThe solution was filtered
  2. washthe cake washed with 10 ml of methylene chloride
  3. additionThe solution (containing 8.4 g of [1,4′]bipiperidinyl-1′-carbonyl chloride)
  4. customsuch for the preparation of Irinotecan

出典と根拠

ORDレコード
ord-8b865cb372234e82bd5519d0c0b4537c
出典データセット
uspto-grants-2010_02
特許番号
US07662964B2

関連ノート

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