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Potassium Carbonate → 4-Piperidinopiperidine-1-carbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride | HCID 11637553 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-Piperidinopiperidine-1-carbonyl chloride | HCID 9813375 | — |
反応手順
[1,4′]bipiperidinyl-1′-carbonyl chloride hydrochloride (9.7 g), methylene chloride (150 ml) and K2CO3 (10.5 g, 2.1 ekv) were charged. The mixture was stirred for about 1 hour. The solution was filtered and the cake washed with 10 ml of methylene chloride. The solution (containing 8.4 g of [1,4′]bipiperidinyl-1′-carbonyl chloride) can be used as such for the preparation of Irinotecan
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07662964B2 |
| 出典データセット | uspto-grants-2010_02 |
| ORD ID | ord-8b865cb372234e82bd5519d0c0b4537c |
| 出典メモ | uspto-grants-2010_02 |