反应详情

[1,4′]bipiperidinyl-1′-carbonyl chloride hydrochloride (9.7 g), methylene chloride (150 ml) and K2CO3 (10.5 g, 2.1 ekv) were charged. The mixture was stirred for about 1 hour. The solution was filtered and the cake washed with 10 ml of methylene chloride. The solution (containing 8.4 g of [1,4′]bipiperidinyl-1′-carbonyl chloride) can be used as such for the preparation of Irinotecan

1. filtrationThe solution was filtered
2. washthe cake washed with 10 ml of methylene chloride
3. additionThe solution (containing 8.4 g of [1,4′]bipiperidinyl-1′-carbonyl chloride)
4. customsuch for the preparation of Irinotecan