(4-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)methanol → 4-methoxy-2-methyl-1H-pyrrolo[2,3-b]pyridine
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]2[NH:9][C:10]([CH2:12]O)=[CH:11][C:4]=12>CO.[OH-].[OH-].[Pd+2]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]2[NH:9][C:10]([CH3:12])=[CH:11][C:4]=12参加物
4
実験手順
A suspension of (4-methoxy-1H-pyrrolo[2,3-b]pyridin-2-yl)methanol 4 (0.90 g, 5.05 mmol) and Pd(OH)2 (100 mg) in methanol containing 4N aq. HCl solution (10 mL) was hydrogenated under hydrogen pressure (50 psi) for 36 h. The acidic mixture was quenched with 1N NaOH solution. Filtration through celite, concentration and purification on silica gel column using 5% methanol in CH2Cl2 to gave 5 as pale yellow syrup. Yield: 0.68 g, 83%; ESI MS: m/z 163.01 (M+1).
後処理
- customfor 36 h
- customThe acidic mixture was quenched with 1N NaOH solution
- filtrationFiltration
- concentrationthrough celite, concentration and purification on silica gel column
出典と根拠
- ORDレコード
- ord-5264f5d2b0c04993aad992605ec1dbed
- 出典データセット
- uspto-grants-2010_02
- 特許番号
- US07666898B2
反応ノート
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