1,2-Dimethoxyethane → Imidazo[1,2-a]pyridine,7-[4-(methylsulfonyl)phenyl]-

Heat a mixture of 7-chloro-imidazo[1,2-a]pyridine (100 g, 152.5 mmol, 1 eq), 4-methylsulfonylphenyl boronic acid (157.3 g, 786.8 mmol, 1.2 eq), Pd(PPh3)4 (19 g, 16.3 mmol, 0.025 eq) and cesium carbonate (472.4 g, 1.44 mol, 2.2 eq) in a mixture of anhydrous DME (2000 mL) and EtOH (1000 mL) at 80° C. under N2 atmosphere for 24 hours. Cool the mixture to room temperature and filter through Celite® to remove Pd catalyst. Add water (5000 mL) and extract this solution with CH2Cl2 (3×2000 mL). Dry the organic phase over MgSO4 and evaporate. Add to the crude 2000 mL of CH2Cl2 and heat to reflux. Remove insoluble materials by filtration and evaporate the solvent to afford a yellow solid. Wash the solid with ethyl ether to give 150 g of the desired compound as a light yellow solid. (Yield: 85%). MS (ES), m/z 273 (M+1).

1. temperatureHeat
2. filtrationfilter through Celite®
3. customto remove Pd catalyst
4. extractionAdd water (5000 mL) and extract this solution with CH2Cl2 (3×2000 mL)
5. dry with materialDry the organic phase over MgSO4
6. customevaporate
7. additionAdd to the crude 2000 mL of CH2Cl2
8. temperatureheat to reflux
9. filtrationRemove insoluble materials by filtration
10. customevaporate the solvent
11. customto afford a yellow solid
12. washWash the solid with ethyl ether

ORDレコード

ord-0a444651b2b04a7e98389084d73b58dc

出典データセット

uspto-grants-2010_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07666879B2