2-(2-Amino-3-benzoylphenyl)-2-(methylsulfanyl)acetamide → Nepafenac

HRID 1446827ノート

反応式

HRID 1446827 の反応式
[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH:16](SC)[C:17]([NH2:19])=[O:18]>O1CCCC1.[Ni]>[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([NH2:19])=[O:18]

参加物

4

反応物 1

HCID 156347272-(2-Amino-3-benzoylphenyl)-2-(methylsulfanyl)acetamide

生成物 1

HCID 151075Nepafenac収率 73.7%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To an agitated solution of 9.7 g (0.032 mole) of 2-amino-3-benzoyl-α-(methylthio)-phenylacetamide in 100 ml of tetrahydrofuran was added 80 g of wet Raney nickel (washed 3 times with water and 3 times with tetrahydrofuran). After 10 minutes the mixture was filtered to remove Raney nickel and the filtrate concentrated under vacuum. The residue was crystallized from isopropyl alcohol to give 6.0 g (73%) of yellow needles, m.p. 178.5°-180.0° C.

後処理

  1. filtrationAfter 10 minutes the mixture was filtered
  2. customto remove Raney nickel
  3. concentrationthe filtrate concentrated under vacuum
  4. customThe residue was crystallized from isopropyl alcohol

出典と根拠

ORDレコード
ord-c56c8a33497240bf8015012682433431
出典データセット
uspto-grants-1982_02
特許番号
US04313949

反応ノート

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