HCID 20552958、化合物 → HCID 70542001、化合物
反応式
[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH:16](SC)[C:17]([NH:19][CH3:20])=[O:18]>O1CCCC1.[Ni]>[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([NH:19][CH3:20])=[O:18]参加物
4
実験手順
A solution of 22.5 g (0.072 mol) of 2-amino-3-benzoyl-α-(methylthio)-N-methylphenylacetamide in 400 ml of tetrahydrofuran was treated with 160 g of wet Raney nickel (washed 3 times with water and 3 times with tetrahydrofuran) for 10 minutes. The mixture was filtered and the filtrate was concentrated. The residue was crystallized from isopropyl alcohol to give 17.2 g (89%) of yellow needles, m.p. 145°-146° C.
後処理
- filtrationThe mixture was filtered
- concentrationthe filtrate was concentrated
- customThe residue was crystallized from isopropyl alcohol
出典と根拠
- ORDレコード
- ord-61870cab486b429da7764d0a2d31b4d8
- 出典データセット
- uspto-grants-1982_02
- 特許番号
- US04313949
反応ノート
読み込み中…