1H-1,2,4-Triazole → 1-(1-Butoxyethyl)-1H-1,2,4-triazole

HRID 1447017ノート

反応式

HRID 1447017 の反応式
Cl[CH:2]([O:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH3:3].[NH:9]1[CH:13]=[N:12][CH:11]=[N:10]1>C(#N)C>[N:9]1([CH:2]([O:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH3:3])[CH:13]=[N:12][CH:11]=[N:10]1

参加物

4

反応物 2

HCID 92571H-1,2,4-TriazoleHCID 12617703HCID 12617703、化合物

生成物 1

HCID 126262961-(1-Butoxyethyl)-1H-1,2,4-triazole

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Crude n-butyl 1-chloroethyl ether (Straus and Weber, Ann, 1932, 498, 124) was treated with 1,2,4-triazole (2.4 g) in acetonitrile (50 ml) to give at once a precipitate. The mixture was refluxed for 2 hours. The solvent was removed under reduced pressure. The residue was treated with water and extracted with diethyl ether. The ethereal layer was washed with water and dried over magnesium sulphate, and the solvent was removed to give the title product as a colourless oil, which was shown by GLC to be 95% pure.

後処理

  1. customto give at once a precipitate
  2. temperatureThe mixture was refluxed for 2 hours
  3. customThe solvent was removed under reduced pressure
  4. additionThe residue was treated with water
  5. extractionextracted with diethyl ether
  6. washThe ethereal layer was washed with water
  7. dry with materialdried over magnesium sulphate
  8. customthe solvent was removed

出典と根拠

ORDレコード
ord-11bb8d243a1a4747983ad5df63fb934e
出典データセット
uspto-grants-1982_02
特許番号
US04315016

反応ノート

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