Sodium Hydroxide → 7-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt

HRID 1447858ノート

反応式

HRID 1447858 の反応式
C([O:3][C:4]([C:6]1[CH:7]=[N:8][N:9]2[C:14]([C:15]3[CH:16]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:19][CH:20]=3)=[CH:13][CH:12]=[N:11][C:10]=12)=[O:5])C.[OH-].[Na+:26]>C(O)C>[Na+:26].[F:23][C:21]([F:22])([F:24])[C:17]1[CH:18]=[CH:19][CH:20]=[C:15]([C:14]2[N:9]3[N:8]=[CH:7][C:6]([C:4]([O-:5])=[O:3])=[C:10]3[N:11]=[CH:12][CH:13]=2)[CH:16]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 111984377-[3-(Trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

生成物 1

HCID 705907417-(alpha,alpha,alpha-Trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid sodium salt

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 3.35 g. of 7-(α,α,α-trifluoro-m-tolyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester, 20 ml. of 5 N sodium hydroxide and 75 ml. of ethanol is heated on a steam bath for 4 hours. The mixture is cooled and solid is recovered by filtration giving the desired product, m.p. 322°-325° C. (dec.).

後処理

  1. additionA mixture of 3.35 g
  2. temperatureThe mixture is cooled
  3. filtrationsolid is recovered by filtration

出典と根拠

ORDレコード
ord-379e00d440b04605a6c71e4c91d54a1f
出典データセット
uspto-grants-1979_12
特許番号
US04178449

反応ノート

読み込み中…