Dimethylformamide dimethyl acetal → 3-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone

HRID 1447863

反応式

HRID 1447863 の反応式
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]([C:9](=[O:12])[CH2:10][CH3:11])[CH:6]=[CH:7][CH:8]=1.CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>>[CH3:20][N:18]([CH3:19])[CH:17]=[C:10]([CH3:11])[C:9]([C:5]1[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=1)=[O:12]

参加物

3

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 137064Propiophenone, 3'-(trifluoromethyl)

生成物 1

HCID 545299423-Dimethylamino-2-methyl-3'-(trifluoromethyl)acrylophenone

実験手順

A mixture of 25 g. of m-trifluoromethylpropiophenone and 25 ml. of dimethylformamide dimethylacetal is refluxed overnight and then evaporated to an oil. The oil is dissolved in hexane and the solution is refrigerated giving crystals of the desired product, m.p. 53°-55° C.

後処理

  1. additionA mixture of 25 g
  2. customevaporated to an oil
  3. dissolutionThe oil is dissolved in hexane

出典と根拠

ORDレコード
ord-f3127b22e1ac4643be4bf18e9fe40f1d
出典データセット
uspto-grants-1979_12
特許番号
US04178449

関連ノート

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