Iodine → 6-ethyl-5-iodo-2-phenyl-4(3H)-pyrimidinone
反応式
[CH2:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH:6][C:5](=[O:15])[CH:4]=1)[CH3:2].[OH-].[Na+].[I:18]I>O>[CH2:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[NH:6][C:5](=[O:15])[C:4]=1[I:18])[CH3:2]参加物
5
反応条件
- 温度
- 50 °C
実験手順
A mixture of 8.18 g (40.9 mmol) of 6-ethyl-2-phenyl-4(3H)-pyrimidinone, 1.68 g (42.0 mmol) of sodium hydroxide, 10.42 g (41.0 mmol) of iodine and 50 mL of water was heated at 50° C. for 4 h. The mixture was cooled and filtered. The white solid collected was dried in a vacuum oven to leave 12.60 g (75%) of 6-ethyl-5-iodo-2-phenyl-4(3H)-pyrimidinone. 1 H-NMR (d6-DMSO) δ 1.25(3H,t), 2.85(2H,q), 7.50(3H,m), 8.15(2H,m).
後処理
- temperatureThe mixture was cooled
- filtrationfiltered
- customThe white solid collected
- customwas dried in a vacuum oven
出典と根拠
- ORDレコード
- ord-be4d8163d3b146d0a463a6fc363aaeaa
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05726124
反応ノート
読み込み中…