Thionyl Chloride → (3,5-Dichloro-6-fluoro-2-pyridyloxy)acetyl chloride

HRID 1448412ノート

反応式

HRID 1448412 の反応式
[Cl:1][C:2]1[C:3]([O:10][CH2:11][C:12]([OH:14])=O)=[N:4][C:5]([F:9])=[C:6]([Cl:8])[CH:7]=1.S(Cl)([Cl:17])=O>>[Cl:1][C:2]1[C:3]([O:10][CH2:11][C:12]([Cl:17])=[O:14])=[N:4][C:5]([F:9])=[C:6]([Cl:8])[CH:7]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 20379575(3,5-Dichloro-6-fluoro-2-pyridyloxy) acetic acid

生成物 1

HCID 20379628(3,5-Dichloro-6-fluoro-2-pyridyloxy)acetyl chloride

実験手順

A solution was prepared by admixing 8.6 grams (0.036 mole) of 3,5-dichloro-6-fluoro-2-pyridyloxy acetic acid in 15 milliliters of thionyl chloride. The mixture was refluxed for about 50 minutes. At the completion of the reaction, the excess thionyl chloride was removed by distillation. The liquid residue was cooled and the crystals which formed were separated. The (3,5-dichloro-6-fluoro-2-pyridyloxy)acetyl chloride product was recovered in a yield of 8.4 grams (92 percent of theoretical). Upon analysis, the product was found to have carbon, hydrogen, chlorine and nitrogen contents of 32.9, 0.9, 41.9 and 5.3 percent, respectively as compared with the theoretical contents of 32.8, 0.4, 41.4 and 5.5 percent, respectively, as calculated for the above-named compound.

後処理

  1. customA solution was prepared
  2. temperatureThe mixture was refluxed for about 50 minutes
  3. customAt the completion of the reaction
  4. customthe excess thionyl chloride was removed by distillation
  5. temperatureThe liquid residue was cooled
  6. customthe crystals which formed
  7. customwere separated
  8. customThe (3,5-dichloro-6-fluoro-2-pyridyloxy)acetyl chloride product was recovered in a yield of 8.4 grams (92 percent of theoretical)

出典と根拠

ORDレコード
ord-85ed653cad734f2d98f19c449b25a007
出典データセット
uspto-grants-1979_12
特許番号
US04180395

反応ノート

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