Sodium Bicarbonate → 2-n-Heptylthio-4-hydroxycyclopent-2-en-1-one

HRID 1448634ノート

反応式

HRID 1448634 の反応式
[CH2:1]([S:8][C:9]1[C:10](=[O:21])[CH2:11][CH:12]([O:14]C2CCCCO2)[CH:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].C(=O)(O)[O-].[Na+].C1CCCCC1.C(OCC)(=O)C>C(O)(=O)C.O.O1CCCC1>[CH2:1]([S:8][C:9]1[C:10](=[O:21])[CH2:11][CH:12]([OH:14])[CH:13]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

参加物

7

反応物 3

HCID 516892Sodium BicarbonateHCID 203803622-n-Heptylthio-4-tetrahydropyranyloxycyclopent-2-en-1-oneHCID 21867204Cyclohexane ethylacetate

生成物 1

HCID 203803872-n-Heptylthio-4-hydroxycyclopent-2-en-1-one収率 99.2%

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒2 回HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

2-n-Heptylthio-4-tetrahydropyranyloxycyclopent-2-en-1-one (80 mg) was dissolved in 5 ml of a mixture of acetic acid, water and tetrahydrofuran in a ratio of 3:1:1 and 2 ml of acetic acid, and the solution was allowed to stand at room temperature for 12 hours. The reaction mixture was neutralized with sodium bicarbonate, and extracted with ethyl acetate. The extract was treated by a customary procedure to afford 58 mg (95% yield) of 2-n-heptylthio-4-hydroxycyclopent-2-en-1-one having a single spot in thin-layer chromatography (cyclohexane/ethyl acetate=4/6). The product had the following characteristics.

後処理

  1. extractionextracted with ethyl acetate
  2. additionThe extract was treated by a customary procedure

出典と根拠

ORDレコード
ord-5f0dfdb5ae0b429abecec7d8bcda2a1e
出典データセット
uspto-grants-1979_12
特許番号
US04180672

反応ノート

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