Diethyl Ether → L-alanyl-L-proline n-pentylamide

HRID 1448745ノート

反応式

HRID 1448745 の反応式
[CH2:1]([NH:6][C:7](=[O:28])[C@@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:27])[C@H:14]([CH3:26])[NH:15]C(OCC1C=CC=CC=1)=O)[CH2:2][CH2:3][CH2:4][CH3:5].CCOCC>Br.C(O)(=O)C>[CH2:1]([NH:6][C:7](=[O:28])[C@@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:27])[C@H:14]([CH3:26])[NH2:15])[CH2:2][CH2:3][CH2:4][CH3:5]

参加物

5

反応物 2

HCID 3283Diethyl EtherHCID 53667817HCID 53667817、化合物

生成物 1

HCID 54383360L-alanyl-L-proline n-pentylamide収率 152.5%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 260Hydrogen Bromide溶媒

実験手順

2.5 g of N-benzyloxycarbonyl-L-alanyl-L-proline n-pentylamide were dissolved in 15 ml of 4-N hydrogen bromide in acetic acid and the solution was stirred for 1 hour at room temperature. 150 ml of dry ether were added. An oil precipitated out and was allowed to settle. The ether was decanted off and the procedure repeated using 150 ml of fresh ether. On evaporation there were obtained 2.5 g of L-alanyl-L-proline n-pentylamide in the form of a white solid.

後処理

  1. customAn oil precipitated out
  2. customThe ether was decanted off
  3. customOn evaporation there

出典と根拠

ORDレコード
ord-f1c080d621b844b1b64286a577ad7823
出典データセット
uspto-grants-1980_02
特許番号
US04187216

反応ノート

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