Ethyl isocyanate → Ethyl-beta-ethylureido-beta-ethoxy acrylate

HRID 1449071ノート

反応式

HRID 1449071 の反応式
[C:1]([O:5][O:6][C:7]([CH2:10][CH3:11])([NH2:9])[CH3:8])(=[O:4])[CH:2]=[CH2:3].[CH2:12]([N:14]=[C:15]=[O:16])[CH3:13]>C(#N)C>[C:1]([O:5][O:6][C:7]([CH2:10][CH3:11])([NH:9][C:15]([NH:14][CH2:12][CH3:13])=[O:16])[CH3:8])(=[O:4])[CH:2]=[CH2:3]

参加物

4

反応物 2

HCID 8022Ethyl isocyanateHCID 86736826Ethylbeta-amino-beta-ethoxy acrylate

生成物 1

HCID 86736827Ethyl-beta-ethylureido-beta-ethoxy acrylate収率 60.9%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 15.9 g of ethyl-β-amino-β-ethoxy acrylate in 30 ml of acetonitrile was added 7.1 g of ethyl isocyanate, and the resulting mixture was allowed to stand at room temperature for one day and one night. The acetonitrile was distilled away under reduced pressure. To the residue was added 100 ml of ether and the system then dried over anhydrous sodium sulfate. The ether was distilled away and the residue was distilled under reduced pressure. Thus, 14 g of ethyl-β-ethylureido-β-ethoxy acrylate of a boiling point of 127° to 130° C. was obtained.

後処理

  1. distillationThe acetonitrile was distilled away under reduced pressure
  2. additionTo the residue was added 100 ml of ether
  3. dry with materialthe system then dried over anhydrous sodium sulfate
  4. distillationThe ether was distilled away
  5. distillationthe residue was distilled under reduced pressure

出典と根拠

ORDレコード
ord-b7874db0e41f449080b95e1129020dc2
出典データセット
uspto-grants-1980_02
特許番号
US04188489

反応ノート

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