Ethanol → 1,2-Benzisothiazol-4-ol, 7-amino-

HRID 1449115ノート

反応式

HRID 1449115 の反応式
CO.C(O)C.C(OC(=O)C)(=O)C.[NH:13]([C:17]1[C:25]2[S:24][N:23]=[CH:22][C:21]=2[C:20]([O:26]C(=O)C)=[CH:19][CH:18]=1)C(C)=O>C(O)(=O)C.C(O)CC>[NH2:13][C:17]1[C:25]2[S:24][N:23]=[CH:22][C:21]=2[C:20]([OH:26])=[CH:19][CH:18]=1

参加物

7

反応物 4

HCID 702EthanolHCID 887MethanolHCID 7918Acetic AnhydrideHCID 203499417-Acetamino-4-acetoxy-1,2-benzisothiazole2 回

生成物 1

HCID 1356171871,2-Benzisothiazol-4-ol, 7-amino-

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒2 回HCID 10311-Propanol溶媒

実験手順

This reduction is as a rule carried out under atmospheric pressure or in a closed vessel under superatmospheric pressure, with or without simultaneous heating. The reaction may be carried out in the presence of a diluent or solvent, for example, a lower alcohol, e.g. methanol, ethanol or preferably propanol, or in the acid required for the reduction, preferably in acetic acid, or in the acylating reaction medium of acetic acid and acetic anhydride, described above, in which 7-acetamino-4-acetoxy-1,2-benzisothiazole is obtained. 7-Acetamino-4-acetoxy-1,2-benzisothiazole can subsequently be deacylated in the above manner to give 7-amino-4-hydroxy-1,2-benzisothiazole.

後処理

  1. customcarried out under atmospheric pressure or in a closed vessel under superatmospheric pressure
  2. customThe reaction
  3. customis obtained

出典と根拠

ORDレコード
ord-38f6917caac942a9a95e10acc735d2e3
出典データセット
uspto-grants-1980_02
特許番号
US04189433

反応ノート

読み込み中…