Tetrahydrofuran → 2-(4-Cinnamoylpiperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline

HRID 1449157ノート

反応式

HRID 1449157 の反応式
O1CCCC1.Cl.[N:7]1([C:13]2[N:22]=[C:21]([NH2:23])[C:20]3[C:15](=[CH:16][C:17]([O:26][CH3:27])=[C:18]([O:24][CH3:25])[CH:19]=3)[N:14]=2)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[C:28](Cl)(=[O:37])[CH:29]=[CH:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>C(N(CC)CC)C>[C:28]([N:10]1[CH2:11][CH2:12][N:7]([C:13]2[N:22]=[C:21]([NH2:23])[C:20]3[C:15](=[CH:16][C:17]([O:26][CH3:27])=[C:18]([O:24][CH3:25])[CH:19]=3)[N:14]=2)[CH2:8][CH2:9]1)(=[O:37])[CH:29]=[CH:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 660233-Phenylprop-2-enoyl chlorideHCID 204738332-Piperazine-4-amino-6,7-dimethoxy quinoline hydrochloride

生成物 1

HCID 30540822-(4-Cinnamoylpiperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

To 10 ml. of tetrahydrofuran were added 1.2 g. of 2-(piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline.hydrochloride and 1.33 g. of triethylamine and the resulting mixture was stirred for 30 minutes. Thereafter, 0.66 g. of cinnamoyl chloride was added thereto and the resulting mixture was stirred at room temperature overnight. The crystalline substance thus separated was recovered by filtration, washed thoroughly with water and ethanol and then dried to afford 0.66 g. of the desired product.

後処理

  1. customThe crystalline substance thus separated
  2. filtrationwas recovered by filtration
  3. washwashed thoroughly with water and ethanol
  4. customdried
  5. customto afford 0.66 g

出典と根拠

ORDレコード
ord-4a7cd3c954d949618dde164126456979
出典データセット
uspto-grants-1980_02
特許番号
US04189484

反応ノート

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