Acetone → HCID 12946261、化合物

HRID 1449379ノート

反応式

HRID 1449379 の反応式
[CH3:1][C:2](C)=[O:3].[F:5][C:6]1([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:11]([OH:12])[NH:10][C:9](=[O:13])[NH:8][C:7]1=[O:14].C(OC(=O)C)(=O)C>N1C=CC=CC=1>[C:2]([O:12][CH:11]1[NH:10][C:9](=[O:13])[NH:8][C:7](=[O:14])[C:6]1([F:5])[C:15]([O:17][CH2:18][CH3:19])=[O:16])(=[O:3])[CH3:1]

参加物

5

反応物 3

HCID 180AcetoneHCID 7918Acetic AnhydrideHCID 12901279HCID 12901279、化合物

生成物 1

HCID 12946261HCID 12946261、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

In 10 ml. of acetone was dissolved 8.80 g. (40 m moles) of ethyl 5-fluoro-6-hydroxy-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylate, and under ice-cooling, 5.10 g. (50 m moles) of acetic anhydride and 10 ml. of pyridine were added. The mixture was reacted at room temperature overnight. (A sample of the reaction mixture was taken, the solvent was distilled off under reduced pressure and the NMR spectrum of the residue was measured to ensure that there had been produced ethyl 6-acetoxy-5-fluoro-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylate

後処理

  1. customThe mixture was reacted at room temperature overnight
  2. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-1d038a9ebab942a190abfc3ea848bdb0
出典データセット
uspto-grants-1980_02
特許番号
US04190656

反応ノート

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