Hydrochloric Acid → HCID 67715287、化合物
反応式
[ClH:1].[CH2:2]([C:5]1[N:9]2[CH2:10][CH2:11][CH2:12][N:13]=[C:8]2[S:7][C:6]=1[C:14]([O:16]CC)=[O:15])[CH2:3][CH3:4].Cl>[OH-].[Na+]>[ClH:1].[CH2:2]([C:5]1[N:9]2[CH2:10][CH2:11][CH2:12][N:13]=[C:8]2[S:7][C:6]=1[C:14]([OH:16])=[O:15])[CH2:3][CH3:4]参加物
4
実験手順
In 110 ml of 1N sodium hydroxide aqueous solution was suspended 9.96 g of ethyl 3-propyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidine-2-carboxylate hydrochloride obtained in Example 11, followed by reflux under heating for 90 minutes. After cooling, the reaction mixture was made acidic with concentrated hydrochloric acid. The precipitated crystals were collected by filtration and washed with acetone to obtain 5.3 g of the titled compound.
後処理
- temperatureby reflux
- temperatureunder heating for 90 minutes
- temperatureAfter cooling
- filtrationThe precipitated crystals were collected by filtration
- washwashed with acetone
出典と根拠
- ORDレコード
- ord-70dc523fc299435ea2441f39d269c343
- 出典データセット
- uspto-grants-1997_02
- 特許番号
- US05599813
反応ノート
読み込み中…