Hydrochloric Acid → N-(3,5-dimethylphenyl)-2-(hydroxyimino)acetamide

HRID 1449555

反応式

HRID 1449555 の反応式
Cl[C:2](Cl)(Cl)[CH:3]([OH:5])O.S([O-])([O-])(=O)=O.[Na+].[Na+].[CH3:15][C:16]1[CH:17]=[C:18]([CH:20]=[C:21]([CH3:23])[CH:22]=1)[NH2:19].Cl.Cl.[NH2:26][OH:27]>O>[CH3:15][C:16]1[CH:17]=[C:18]([NH:19][C:3](=[O:5])[CH:2]=[N:26][OH:27])[CH:20]=[C:21]([CH3:23])[CH:22]=1

参加物

7

反応物 5

HCID 313Hydrochloric AcidHCID 2707Chloral HydrateHCID 79493,5-DimethylanilineHCID 24436Sodium SulfateHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 53405864N-(3,5-dimethylphenyl)-2-(hydroxyimino)acetamide収率 95%

試薬・触媒・溶媒 1

HCID 962Water溶媒3 回

実験手順

To a solution of chloral hydrate (14.1 g, 85.24 mM) and sodium sulfate (88.2g, 7.53 eq.) in 270 mL of water was added a solution of 3,5-dimethylaniline in a solution of concentrated HCl (16 mL) and water (51 mL), whereupon an off-white precipitate formed. The mixture was stirred for 10 min prior to adding an aqueous solution of hydroxylamine hydrochloride (17.4 g, 250 mM) in water (50 mL) and then heated at reflux for 10 min during which time the solids dissolved and a tan precipitate formed. The mixture was cooled and filtered, and the collected solids were air dried to yield the title compound (15.0 g, 95%).

後処理

  1. customwhereupon an off-white precipitate formed
  2. temperatureheated
  3. temperatureat reflux for 10 min during which time the solids
  4. dissolutiondissolved
  5. customa tan precipitate formed
  6. temperatureThe mixture was cooled
  7. filtrationfiltered
  8. customdried

出典と根拠

ORDレコード
ord-d55d3fed20f641cea9f4145d448636da
出典データセット
uspto-grants-1997_02
特許番号
US05599814

関連ノート

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