N-Iodosuccinimide → 3-(4-Chlorophenyl)-7-hydroxy-8-iodo-2-isopropyl-chromen-4-one

HRID 14496

反応式

HRID 14496 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][C:13]([OH:19])=[CH:14][CH:15]=3)[O:10][C:9]=2[CH:20]([CH3:22])[CH3:21])=[CH:4][CH:3]=1.[I:23]N1C(=O)CCC1=O>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:17](=[O:18])[C:16]3[C:11](=[C:12]([I:23])[C:13]([OH:19])=[CH:14][CH:15]=3)[O:10][C:9]=2[CH:20]([CH3:22])[CH3:21])=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 120273N-IodosuccinimideHCID 162024513-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one

生成物 1

HCID 597242463-(4-Chlorophenyl)-7-hydroxy-8-iodo-2-isopropyl-chromen-4-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

3-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one (2.3 g, 7.31 mmol) is suspended in dry dichloromethane (140 ml) at room temperature. N-iodosuccinimide (1.73 g, 7.67 mmol) is added, and the mixture is stirred vigorously at room temperature for 30 min. The mixture is diluted with dichloromethane (60 ml), washed with water (3×100 ml) and saturated brine (50 ml), dried (MgSO4) and filtered, and the filtrate is evaporated to give a pale pink solid.

後処理

  1. washwashed with water (3×100 ml) and saturated brine (50 ml)
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customthe filtrate is evaporated
  5. customto give a pale pink solid

出典と根拠

ORDレコード
ord-d432949c0c7046e1843b5cf1467f7cf1
出典データセット
uspto-grants-2010_06
特許番号
US07732435B2

関連ノート

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