Iodoethane → HCID 44295455、化合物

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[NH:9][C:10](=[S:16])[NH:11][CH2:12][C:13](N)=[O:14].[CH2:17](I)[CH3:18]>>[Cl:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[N:9]1[C:13](=[O:14])[CH2:12][N:11]=[C:10]1[S:16][CH2:17][CH3:18]

参加物

反応物 2

HCID 6340Iodoethane

HCID 54569709HCID 54569709、化合物

生成物 1

HCID 44295455HCID 44295455、化合物収率 44.3%

実験手順

The title compound was prepared by the procedure described in Example 2 using 27.8 g of 2-[3-(2,6-dichlorophenyl)-thioureido]-acetamide and 31.2 g of ethyl iodide. 12.8 g of the title compound was obtained, m.p. 122°-124° C. Anal. Calcd. for. C11H10Cl2N2O S: C, 45.69; H, 3.49; N, 9.69. Found: C, 45.62; H, 3.33; N, 9.43. Mass spectrum (+FAB, [M+H]+) m/z 289/291/293. 1H-NMR (DMSO-d6 ; 400 MHz) δ7.72 (s, 1H), 7.70 (s, 1H), 7.58 (t, 1H), 4.50 (s, 2H), 3.10 (q, 2H), and 1.27 ppm (t, 3H).

後処理

customThe title compound was prepared by the procedure

出典と根拠

ORDレコード: ord-1acf68315a4d4559aa7e6751efcef37e
出典データセット: uspto-grants-1997_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05599829

反応ノート

読み込み中…

参加物