Isopropylamine → 3-Chloro-N-(propan-2-yl)pyrazin-2-amine
反応式
Cl[C:2]1[C:7]([Cl:8])=[N:6][CH:5]=[CH:4][N:3]=1.[CH:9]([NH2:12])([CH3:11])[CH3:10]>C1(C)C=CC=CC=1>[Cl:8][C:7]1[C:2]([NH:12][CH:9]([CH3:11])[CH3:10])=[N:3][CH:4]=[CH:5][N:6]=1参加物
4
実験手順
A solution of 2,3-dichloropyrazine (2.0 g) and isopropylamine (2.3 g) in toluene (8 ml) is refluxed for 40 hr. The mixture is cooled and filtered to remove isopropylamine hydrochloride. The filtrate is concentrated in vacuo to a residue which is diluted with an aqueous sodium hydroxide solution (10%) and dichloromethane. The phases are separated. The dichloromethane phase is washed with saline, dried over sodium sulfate, and concentrated to give the title compound, NMR (CDCl3) 1.28, 4.21, 5.02, 7.54 and 7.94 δ.
後処理
- temperatureThe mixture is cooled
- filtrationfiltered
- customto remove isopropylamine hydrochloride
- concentrationThe filtrate is concentrated in vacuo to a residue which
- additionis diluted with an aqueous sodium hydroxide solution (10%) and dichloromethane
- customThe phases are separated
- washThe dichloromethane phase is washed with saline
- dry with materialdried over sodium sulfate
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-71370d5db69d4a06bc1027d8bd77c1af
- 出典データセット
- uspto-grants-1997_02
- 特許番号
- US05599930
反応ノート
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